Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.
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Retrieved from ” https: Traditional forms of medicine, especially the herbal products deployed for centuries in many parts of the world, could be good alternative for scientific investigation due to their attributes against tumor cell lines.
Those of Salvia verbenaca were collected on March at the locality called Ain Aouda, in the Cinerrea region, Morocco. The collected aerial parts were left under shade at room temperature until complete drying.
This study is expected to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives cinerra further investigations on other types of cancer cell lines. Comparative evaluation of antioxidant and insecticidal properties of essential oils from five Moroccan aromatic herbs.
Growing Wildly in the Middle East: The concentrations that inhibit half of the cell population IC 50 were obtained by modeling the percentage of cytotoxicity versus concentration of extracts. For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was observed indicating a dose dependent effect.
This work was therefore initiated in order to evaluate the in vitro antiproliferative effect of Cotula cinerea and Salvia verbenaca extracts and essential oil against tumor RD and Vero cell lines.
Showing of 22 references. Abstract The objective of this cotua was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and cotuka -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea. Results and Discussion Cijerea an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca.
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The test is based on the biotransformation of MTT into formazan crystals by mitochondrial dehydrogenases of living cells. Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc. In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca.
The Royal Society of New Zealand. The two tumor tested cell lines used in this study were RD Human Embryonal Rhabdomyosarcoma cancerous cell lines: Hilliard Cotula loganii Hutch. These two species were obtained from the National Institute of Health, Rabat, Morocco, and were cultivated as previously described by Aneb et al.
The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea.
The essential oil of Cotula cinerea aerial parts was extracted by hydrodistillation using a Clevenger-type apparatus. Skip to search form Skip to main content.
BioMed Research International
Subscribe to Table of Contents Alerts. Table of Contents Alerts. On the other hand, different results were obtained and Cotula cinerea essential oil was the most cytotoxic with the lowest IC 50 value The exact mechanism through which the explored extracts act on each tumor cell line is obviously difficult to highlight.
In the genus was subdivided by George Bentham  into three sections.
Flavonoids from Cotula cinerea Del
The current widely used cancer treatments such as surgery, radiotherapy, cotkla therapy, and chemotherapy are very expensive and cause several side and adverse effects [ 4 ]. The action and mechanism of Cotula cinerea essential oil cptula very complex involving several targeting pathways as previously reported [ 5 ]. Antiproliferative activity at different concentrations of the essential oil and different extracts of Cotula cinerea top and Salvia verbenaca bottom against Vero cell line by MTT assay.
The maceration process was repeated twice during 24 h each in order to achieve an exhaustive extraction. After 24 h incubation, cells were then treated with the essential oil of Cotula cinerea or its extracts hexane, ethyl acetate, and n -butanol in addition to those of Salvia verbenaca. In addition, these mixtures could act in a synergic cothla in an antagonism manner.